2104100 - Disclosure - Acquisitions link:presentationLink link:calculationLink link:definitionLink 2404408 - Disclosure - Acquisitions - Acquisition of ACAM2000 Business (Details) link:presentationLink link:calculationLink link:definitionLink 2404407 - Disclosure - Acquisitions - Acquisition of ACAM2000 Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 2404409 - Disclosure - Acquisitions - Acquisition of Raxibacumab Asset (Details) link:presentationLink link:calculationLink link:definitionLink 2404402 - Disclosure - Acquisitions - Adapt Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 2404404 - Disclosure - Acquisitions - Adapt Preliminary Allocation of Purchase Price (Details) link:presentationLink link:calculationLink link:definitionLink 2404403 - Disclosure - Acquisitions - Adapt Preliminary Purchase Consideration (Details) link:presentationLink link:calculationLink link:definitionLink 2404405 - Disclosure - Acquisitions - PaxVax Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 2404406 - Disclosure - Acquisitions - PaxVax Preliminary Allocation of Purchase Price (Details) link:presentationLink link:calculationLink link:definitionLink 2304301 - Disclosure - Acquisitions (Tables) link:presentationLink link:calculationLink link:definitionLink 1001000 - Statement - Consolidated Balance Sheets link:presentationLink link:calculationLink link:definitionLink 1001501 - Statement - Consolidated Balance Sheets (Parenthetical) link:presentationLink link:calculationLink link:definitionLink 1005000 - Statement - Consolidated Statement of Changes in Stockholders' Equity link:presentationLink link:calculationLink link:definitionLink 1005501 - Statement - Consolidated Statement of Changes in Stockholders' Equity (Parenthetical) link:presentationLink link:calculationLink link:definitionLink 1004000 - Statement - Consolidated Statements of Cash Flows link:presentationLink link:calculationLink link:definitionLink 1003000 - Statement - Consolidated Statements of Comprehensive Income link:presentationLink link:calculationLink link:definitionLink 1002000 - Statement - Consolidated Statements of Operations link:presentationLink link:calculationLink link:definitionLink 0001000 - Document - Cover Page link:presentationLink link:calculationLink link:definitionLink 2113100 - Disclosure - Defined benefit and 401(k) savings plan link:presentationLink link:calculationLink link:definitionLink 2413405 - Disclosure - Defined benefit and 401(k) savings plan - Accumulated Other Comprehensive Loss Before Income Tax (Details) link:presentationLink link:calculationLink link:definitionLink 2413403 - Disclosure - Defined benefit and 401(k) savings plan - Components of Net Periodic Pension Cost (Details) link:presentationLink link:calculationLink link:definitionLink 2413406 - Disclosure - Defined benefit and 401(k) savings plan - Expected Future Benefits Payments (Details) link:presentationLink link:calculationLink link:definitionLink 2413407 - Disclosure - Defined benefit and 401(k) savings plan - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 2413402 - Disclosure - Defined benefit and 401(k) savings plan - Swiss Plan Funded Status (Details) link:presentationLink link:calculationLink link:definitionLink 2313301 - Disclosure - Defined benefit and 401(k) savings plan (Tables) link:presentationLink link:calculationLink link:definitionLink 2413404 - Disclosure - Defined benefit and 401(k) savings plan - Weighted Average Assumptions (Details) link:presentationLink link:calculationLink link:definitionLink 2110100 - Disclosure - Derivative Instruments link:presentationLink link:calculationLink link:definitionLink 2410405 - Disclosure - Derivative Instruments - Cash Flow Hedging on AOCI (Details) link:presentationLink link:calculationLink link:definitionLink 2410402 - Disclosure - Derivative Instruments - Derivative Designated as Cash Flow Hedges (Details) link:presentationLink link:calculationLink link:definitionLink 2410404 - Disclosure - Derivative Instruments - Fair Value by Balance Sheet Location (Details) link:presentationLink link:calculationLink link:definitionLink 2410403 - Disclosure - Derivative Instruments - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 2310301 - Disclosure - Derivative Instruments (Tables) link:presentationLink link:calculationLink link:definitionLink 2115100 - Disclosure - Earnings per share link:presentationLink link:calculationLink link:definitionLink 2415402 - Disclosure - Earnings per share (Details) link:presentationLink link:calculationLink link:definitionLink 2315301 - Disclosure - Earnings per share (Tables) link:presentationLink link:calculationLink link:definitionLink 2105100 - Disclosure - Fair value measurements link:presentationLink link:calculationLink link:definitionLink 2405402 - Disclosure - Fair value measurements (Details) link:presentationLink link:calculationLink link:definitionLink 2405403 - Disclosure - Fair value measurements - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 2305301 - Disclosure - Fair value measurements (Tables) link:presentationLink link:calculationLink link:definitionLink 2112100 - Disclosure - Income taxes link:presentationLink link:calculationLink link:definitionLink 2412403 - Disclosure - Income taxes - Components of the Provisions for Income Taxes (Details) link:presentationLink link:calculationLink link:definitionLink 2412402 - Disclosure - Income taxes - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 2412404 - Disclosure - Income taxes - Net Deferred Tax Asset (Liability) (Details) link:presentationLink link:calculationLink link:definitionLink 2412405 - Disclosure - Income taxes - Reconciliation (Details) link:presentationLink link:calculationLink link:definitionLink 2312301 - Disclosure - Income taxes (Tables) link:presentationLink link:calculationLink link:definitionLink 2412406 - Disclosure - Income taxes - Unrecognized Tax Benefits (Details) link:presentationLink link:calculationLink link:definitionLink 2108100 - Disclosure - Intangible assets and goodwill link:presentationLink link:calculationLink link:definitionLink 2408404 - Disclosure - Intangible assets and goodwill - Future Amortization Expense (Details) link:presentationLink link:calculationLink link:definitionLink 2408403 - Disclosure - Intangible assets and goodwill - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 2408402 - Disclosure - Intangible assets and goodwill - Schedule of Finite-lived Intangible Assets (Details) link:presentationLink link:calculationLink link:definitionLink 2408405 - Disclosure - Intangible assets and goodwill - Summary Changes in Goodwill (Details) link:presentationLink link:calculationLink link:definitionLink 2308301 - Disclosure - Intangible assets and goodwill (Tables) link:presentationLink link:calculationLink link:definitionLink 2106100 - Disclosure - Inventories link:presentationLink link:calculationLink link:definitionLink 2406402 - Disclosure - Inventories (Details) link:presentationLink link:calculationLink link:definitionLink 2306301 - Disclosure - Inventories (Tables) link:presentationLink link:calculationLink link:definitionLink 2114100 - Disclosure - Leases link:presentationLink link:calculationLink link:definitionLink 2414403 - Disclosure - Leases - Components of Lease Expense (Details) link:presentationLink link:calculationLink link:definitionLink 2414402 - Disclosure - Leases - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 2414404 - Disclosure - Leases - Supplemental Balance Sheet Information (Details) link:presentationLink link:calculationLink link:definitionLink 2314301 - Disclosure - Leases (Tables) link:presentationLink link:calculationLink link:definitionLink 2119100 - Disclosure - Litigation link:presentationLink link:calculationLink link:definitionLink 2109100 - Disclosure - Long-term debt link:presentationLink link:calculationLink link:definitionLink 2409402 - Disclosure - Long-term debt - Components of Long-term Indebtedness (Details) link:presentationLink link:calculationLink link:definitionLink 2409404 - Disclosure - Long-term debt - Convertible Senior Notes (Details) link:presentationLink link:calculationLink link:definitionLink 2409405 - Disclosure - Long-term debt - Future Debt Payments of Long-term Indebtedness (Details) link:presentationLink link:calculationLink link:definitionLink 2409403 - Disclosure - Long-term debt - Senior Secured Credit Agreement (Details) link:presentationLink link:calculationLink link:definitionLink 2309301 - Disclosure - Long-term debt (Tables) link:presentationLink link:calculationLink link:definitionLink 2101100 - Disclosure - Nature of the business and organization link:presentationLink link:calculationLink link:definitionLink 2401401 - Disclosure - Nature of the business and organization (Details) link:presentationLink link:calculationLink link:definitionLink 2107100 - Disclosure - Property, plant and equipment link:presentationLink link:calculationLink link:definitionLink 2407402 - Disclosure - Property, plant and equipment (Details) link:presentationLink link:calculationLink link:definitionLink 2307301 - Disclosure - Property, plant and equipment (Tables) link:presentationLink link:calculationLink link:definitionLink 2116100 - Disclosure - Purchase commitments link:presentationLink link:calculationLink link:definitionLink 2416401 - Disclosure - Purchase commitments (Details) link:presentationLink link:calculationLink link:definitionLink 2118100 - Disclosure - Quarterly financial data (unaudited) link:presentationLink link:calculationLink link:definitionLink 2418402 - Disclosure - Quarterly financial data (unaudited) (Details) link:presentationLink link:calculationLink link:definitionLink 2318301 - Disclosure - Quarterly financial data (unaudited) (Tables) link:presentationLink link:calculationLink link:definitionLink 2103100 - Disclosure - Revenue recognition link:presentationLink link:calculationLink link:definitionLink 2403406 - Disclosure - Revenue recognition - Accounts Receivable (Details) link:presentationLink link:calculationLink link:definitionLink 2403405 - Disclosure - Revenue recognition - Contract Liabilities (Details) link:presentationLink link:calculationLink link:definitionLink 2403404 - Disclosure - Revenue recognition - Disaggregation of Revenue (Details) link:presentationLink link:calculationLink link:definitionLink 2403402 - Disclosure - Revenue recognition - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 2403403 - Disclosure - Revenue recognition - Remaining Performance Obligation (Details) link:presentationLink link:calculationLink link:definitionLink 2303301 - Disclosure - Revenue recognition (Tables) link:presentationLink link:calculationLink link:definitionLink 2120100 - Disclosure - Schedule II - Valuation and Qualifying Accounts link:presentationLink link:calculationLink link:definitionLink 2420401 - Disclosure - Schedule II - Valuation and Qualifying Accounts (Details) link:presentationLink link:calculationLink link:definitionLink 2117100 - Disclosure - Segment information link:presentationLink link:calculationLink link:definitionLink 2417402 - Disclosure - Segment information - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 2417403 - Disclosure - Segment information - Product Sales (Details) link:presentationLink link:calculationLink link:definitionLink 2317301 - Disclosure - Segment information (Tables) link:presentationLink link:calculationLink link:definitionLink 2111100 - Disclosure - Stockholders' equity link:presentationLink link:calculationLink link:definitionLink 2411406 - Disclosure - Stockholders' equity - Changes in Accumulated Other Comprehensive Loss (Details) link:presentationLink link:calculationLink link:definitionLink 2411402 - Disclosure - Stockholders' equity - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 2411405 - Disclosure - Stockholders' equity - Stock-based Compensation Expense (Details) link:presentationLink link:calculationLink link:definitionLink 2411404 - Disclosure - Stockholders' equity - Stock Options and Restricted Stock Units (Details) link:presentationLink link:calculationLink link:definitionLink 2411403 - Disclosure - Stockholders' equity - Stock Options Valuation Assumptions (Details) link:presentationLink link:calculationLink link:definitionLink 2311301 - Disclosure - Stockholders' equity (Tables) link:presentationLink link:calculationLink link:definitionLink 2102100 - Disclosure - Summary of significant accounting policies link:presentationLink link:calculationLink link:definitionLink 2402407 - Disclosure - Summary of significant accounting policies - Accounting for Stock-based Compensation (Details) link:presentationLink link:calculationLink link:definitionLink 2402405 - Disclosure - Summary of significant accounting policies - Asset Impairment Analysis (Details) link:presentationLink link:calculationLink link:definitionLink 2402403 - Disclosure - Summary of significant accounting policies - Concentration Risk (Details) link:presentationLink link:calculationLink link:definitionLink 2402406 - Disclosure - Summary of significant accounting policies - Earnings Per Share (Details) link:presentationLink link:calculationLink link:definitionLink 2402404 - Disclosure - Summary of significant accounting policies - Estimated Useful Lives (Details) link:presentationLink link:calculationLink link:definitionLink 2202201 - Disclosure - Summary of significant accounting policies (Policies) link:presentationLink link:calculationLink link:definitionLink 2402408 - Disclosure - Summary of significant accounting policies - Recently Issued Accounting Standards (Details) link:presentationLink link:calculationLink link:definitionLink 2302302 - Disclosure - Summary of significant accounting policies (Tables) link:presentationLink link:calculationLink link:definitionLink