0001001 - Document - Cover Page link:presentationLink link:calculationLink link:definitionLink 1001002 - Statement - Consolidated Balance Sheets link:presentationLink link:calculationLink link:definitionLink 1002003 - Statement - Consolidated Balance Sheets (Parenthetical) link:presentationLink link:calculationLink link:definitionLink 1003004 - Statement - Consolidated Statements of Operations link:presentationLink link:calculationLink link:definitionLink 1004005 - Statement - Consolidated Statements of Comprehensive Income link:presentationLink link:calculationLink link:definitionLink 1005006 - Statement - Consolidated Statements of Cash Flows link:presentationLink link:calculationLink link:definitionLink 1006007 - Statement - Consolidated Statement of Changes in Stockholders' Equity link:presentationLink link:calculationLink link:definitionLink 1007008 - Statement - Consolidated Statement of Changes in Stockholders' Equity (Parenthetical) link:presentationLink link:calculationLink link:definitionLink 2101101 - Disclosure - Nature of the business and organization link:presentationLink link:calculationLink link:definitionLink 2402401 - Disclosure - Nature of the business and organization (Details) link:presentationLink link:calculationLink link:definitionLink 2103102 - Disclosure - Summary of significant accounting policies link:presentationLink link:calculationLink link:definitionLink 2204201 - Disclosure - Summary of significant accounting policies (Policies) link:presentationLink link:calculationLink link:definitionLink 2305301 - Disclosure - Summary of significant accounting policies (Tables) link:presentationLink link:calculationLink link:definitionLink 2406402 - Disclosure - Summary of significant accounting policies - Concentration Risk (Details) link:presentationLink link:calculationLink link:definitionLink 2407403 - Disclosure - Summary of significant accounting policies - Estimated Useful Lives (Details) link:presentationLink link:calculationLink link:definitionLink 2408404 - Disclosure - Summary of significant accounting policies - Asset Impairment Analysis (Details) link:presentationLink link:calculationLink link:definitionLink 2409405 - Disclosure - Summary of significant accounting policies - Accounting for Stock-based Compensation (Details) link:presentationLink link:calculationLink link:definitionLink 2110103 - Disclosure - Revenue recognition link:presentationLink link:calculationLink link:definitionLink 2311302 - Disclosure - Revenue recognition (Tables) link:presentationLink link:calculationLink link:definitionLink 2412406 - Disclosure - Revenue recognition - Disaggregation of Revenue (Details) link:presentationLink link:calculationLink link:definitionLink 2413407 - Disclosure - Revenue recognition - Percentage of Product Sales (Details) link:presentationLink link:calculationLink link:definitionLink 2414408 - Disclosure - Revenue recognition - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 2415409 - Disclosure - Revenue recognition - Remaining Performance Obligation (Details) link:presentationLink link:calculationLink link:definitionLink 2415409 - Disclosure - Revenue recognition - Remaining Performance Obligation (Details) link:presentationLink link:calculationLink link:definitionLink 2416410 - Disclosure - Revenue recognition - Contract Liabilities (Details) link:presentationLink link:calculationLink link:definitionLink 2417411 - Disclosure - Revenue recognition - Performance Obligations (Details) link:presentationLink link:calculationLink link:definitionLink 2417411 - Disclosure - Revenue recognition - Performance Obligations (Details) link:presentationLink link:calculationLink link:definitionLink 2418412 - Disclosure - Revenue recognition - Accounts Receivable (Details) link:presentationLink link:calculationLink link:definitionLink 2119104 - Disclosure - Acquisitions link:presentationLink link:calculationLink link:definitionLink 2320303 - Disclosure - Acquisitions (Tables) link:presentationLink link:calculationLink link:definitionLink 2421413 - Disclosure - Acquisitions - Adapt Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 2422414 - Disclosure - Acquisitions - Adapt Preliminary Purchase Consideration (Details) link:presentationLink link:calculationLink link:definitionLink 2423415 - Disclosure - Acquisitions - Adapt Preliminary Allocation of Purchase Price (Details) link:presentationLink link:calculationLink link:definitionLink 2424416 - Disclosure - Acquisitions - PaxVax Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 2425417 - Disclosure - Acquisitions - PaxVax Preliminary Allocation of Purchase Price (Details) link:presentationLink link:calculationLink link:definitionLink 2126105 - Disclosure - Fair value measurements link:presentationLink link:calculationLink link:definitionLink 2327304 - Disclosure - Fair value measurements (Tables) link:presentationLink link:calculationLink link:definitionLink 2428418 - Disclosure - Fair value measurements - Reconciliation of the Contingent Consideration Liabilities Measured at Fair Value (Details) link:presentationLink link:calculationLink link:definitionLink 2429419 - Disclosure - Fair value measurements - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 2430420 - Disclosure - Fair value measurements - Level 3 Significant Unobservable Inputs (Details) link:presentationLink link:calculationLink link:definitionLink 2131106 - Disclosure - Inventories link:presentationLink link:calculationLink link:definitionLink 2332305 - Disclosure - Inventories (Tables) link:presentationLink link:calculationLink link:definitionLink 2433421 - Disclosure - Inventories (Details) link:presentationLink link:calculationLink link:definitionLink 2434422 - Disclosure - Inventories - Additional Information (Details) link:presentationLink link:calculationLink link:definitionLink 2135107 - Disclosure - Property, plant and equipment link:presentationLink link:calculationLink link:definitionLink 2336306 - Disclosure - Property, plant and equipment (Tables) link:presentationLink link:calculationLink link:definitionLink 2437423 - Disclosure - Property, plant and equipment (Details) link:presentationLink link:calculationLink link:definitionLink 2138108 - Disclosure - Intangible assets and goodwill link:presentationLink link:calculationLink link:definitionLink 2339307 - Disclosure - Intangible assets and goodwill (Tables) link:presentationLink link:calculationLink link:definitionLink 2440424 - Disclosure - Intangible assets and goodwill - Schedule of Finite-lived Intangible Assets (Details) link:presentationLink link:calculationLink link:definitionLink 2441425 - Disclosure - Intangible assets and goodwill - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 2442426 - Disclosure - Intangible assets and goodwill - Future Amortization Expense (Details) link:presentationLink link:calculationLink link:definitionLink 2443427 - Disclosure - Intangible assets and goodwill - Summary Changes in Goodwill (Details) link:presentationLink link:calculationLink link:definitionLink 2144109 - Disclosure - Long-term debt link:presentationLink link:calculationLink link:definitionLink 2345308 - Disclosure - Long-term debt (Tables) link:presentationLink link:calculationLink link:definitionLink 2446428 - Disclosure - Long-term debt - Components of Long-term Indebtedness (Details) link:presentationLink link:calculationLink link:definitionLink 2447429 - Disclosure - Long-term debt - Senior Unsecured Notes (Details) link:presentationLink link:calculationLink link:definitionLink 2448430 - Disclosure - Long-term debt - Senior Secured Credit Agreement (Details) link:presentationLink link:calculationLink link:definitionLink 2449431 - Disclosure - Long-term debt - Convertible Senior Notes (Details) link:presentationLink link:calculationLink link:definitionLink 2450432 - Disclosure - Long-term debt - Future Debt Payments of Long-term Indebtedness (Details) link:presentationLink link:calculationLink link:definitionLink 2151110 - Disclosure - Derivative Instruments and hedging activities link:presentationLink link:calculationLink link:definitionLink 2352309 - Disclosure - Derivative Instruments and hedging activities (Tables) link:presentationLink link:calculationLink link:definitionLink 2453433 - Disclosure - Derivative Instruments and hedging activities - Derivative Designated as Cash Flow Hedges (Details) link:presentationLink link:calculationLink link:definitionLink 2454434 - Disclosure - Derivative Instruments and hedging activities - Fair Value by Balance Sheet Location (Details) link:presentationLink link:calculationLink link:definitionLink 2455435 - Disclosure - Derivative Instruments and hedging activities - Cash Flow Hedging on AOCI (Details) link:presentationLink link:calculationLink link:definitionLink 2456436 - Disclosure - Derivative Instruments and hedging activities - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 2157111 - Disclosure - Stockholders' equity link:presentationLink link:calculationLink link:definitionLink 2358310 - Disclosure - Stockholders' equity (Tables) link:presentationLink link:calculationLink link:definitionLink 2459437 - Disclosure - Stockholders' equity - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 2460438 - Disclosure - Stockholders' equity - Stock Options Valuation Assumptions (Details) link:presentationLink link:calculationLink link:definitionLink 2461439 - Disclosure - Stockholders' equity - Stock Options and Restricted Stock Units (Details) link:presentationLink link:calculationLink link:definitionLink 2462440 - Disclosure - Stockholders' equity - Stock-based Compensation Expense (Details) link:presentationLink link:calculationLink link:definitionLink 2463441 - Disclosure - Stockholders' equity - Changes in Accumulated Other Comprehensive Loss (Details) link:presentationLink link:calculationLink link:definitionLink 2164112 - Disclosure - Income taxes link:presentationLink link:calculationLink link:definitionLink 2365311 - Disclosure - Income taxes (Tables) link:presentationLink link:calculationLink link:definitionLink 2466442 - Disclosure - Income taxes - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 2467443 - Disclosure - Income taxes - Components of the Provisions for Income Taxes (Details) link:presentationLink link:calculationLink link:definitionLink 2468444 - Disclosure - Income taxes - Net Deferred Tax Asset (Liability) (Details) link:presentationLink link:calculationLink link:definitionLink 2469445 - Disclosure - Income taxes - Reconciliation (Details) link:presentationLink link:calculationLink link:definitionLink 2470446 - Disclosure - Income taxes - Unrecognized Tax Benefits (Details) link:presentationLink link:calculationLink link:definitionLink 2171113 - Disclosure - Defined benefit and 401(k) savings plan link:presentationLink link:calculationLink link:definitionLink 2372312 - Disclosure - Defined benefit and 401(k) savings plan (Tables) link:presentationLink link:calculationLink link:definitionLink 2473447 - Disclosure - Defined benefit and 401(k) savings plan - Swiss Plan Funded Status (Details) link:presentationLink link:calculationLink link:definitionLink 2474448 - Disclosure - Defined benefit and 401(k) savings plan - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 2475449 - Disclosure - Defined benefit and 401(k) savings plan - Components of Net Periodic Pension Cost (Details) link:presentationLink link:calculationLink link:definitionLink 2476450 - Disclosure - Defined benefit and 401(k) savings plan - Weighted Average Assumptions (Details) link:presentationLink link:calculationLink link:definitionLink 2477451 - Disclosure - Defined benefit and 401(k) savings plan - Accumulated Other Comprehensive Loss Before Income Tax (Details) link:presentationLink link:calculationLink link:definitionLink 2478452 - Disclosure - Defined benefit and 401(k) savings plan - Expected Future Benefits Payments (Details) link:presentationLink link:calculationLink link:definitionLink 2179114 - Disclosure - Leases link:presentationLink link:calculationLink link:definitionLink 2380313 - Disclosure - Leases (Tables) link:presentationLink link:calculationLink link:definitionLink 2481453 - Disclosure - Leases - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 2482454 - Disclosure - Leases - Components of Lease Expense (Details) link:presentationLink link:calculationLink link:definitionLink 2483455 - Disclosure - Leases - Supplemental Balance Sheet Information (Details) link:presentationLink link:calculationLink link:definitionLink 2184115 - Disclosure - Earnings per share link:presentationLink link:calculationLink link:definitionLink 2385314 - Disclosure - Earnings per share (Tables) link:presentationLink link:calculationLink link:definitionLink 2486456 - Disclosure - Earnings per share (Details) link:presentationLink link:calculationLink link:definitionLink 2187116 - Disclosure - Purchase commitments link:presentationLink link:calculationLink link:definitionLink 2488457 - Disclosure - Purchase commitments (Details) link:presentationLink link:calculationLink link:definitionLink 2189117 - Disclosure - Segment information link:presentationLink link:calculationLink link:definitionLink 2490458 - Disclosure - Segment information - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 2191118 - Disclosure - Quarterly financial data (unaudited) link:presentationLink link:calculationLink link:definitionLink 2392315 - Disclosure - Quarterly financial data (unaudited) (Tables) link:presentationLink link:calculationLink link:definitionLink 2493459 - Disclosure - Quarterly financial data (unaudited) (Details) link:presentationLink link:calculationLink link:definitionLink 2194119 - Disclosure - Litigation link:presentationLink link:calculationLink link:definitionLink 2195120 - Disclosure - Schedule II - Valuation and Qualifying Accounts link:presentationLink link:calculationLink link:definitionLink 2496460 - Disclosure - Schedule II - Valuation and Qualifying Accounts (Details) link:presentationLink link:calculationLink link:definitionLink