001000 - Statement - Consolidated Balance Sheets link:presentationLink link:calculationLink link:definitionLink 001010 - Statement - Consolidated Balance Sheets (Parenthetical) link:presentationLink link:calculationLink link:definitionLink 002000 - Statement - Consolidated Statements of Operations link:presentationLink link:calculationLink link:definitionLink 003000 - Statement - Consolidated Statements of Cash Flows link:presentationLink link:calculationLink link:definitionLink 004000 - Statement - Consolidated Statement of Changes in Stockholders' Equity link:presentationLink link:calculationLink link:definitionLink 006010 - Disclosure - Nature of the business and organization link:presentationLink link:calculationLink link:definitionLink 006020 - Disclosure - Summary of significant accounting policies link:presentationLink link:calculationLink link:definitionLink 006030 - Disclosure - Acquisition of Trubion Pharmaceuticals, Inc. link:presentationLink link:calculationLink link:definitionLink 006040 - Disclosure - Fair value measurements link:presentationLink link:calculationLink link:definitionLink 006050 - Disclosure - Investments link:presentationLink link:calculationLink link:definitionLink 006060 - Disclosure - Accounts receivable link:presentationLink link:calculationLink link:definitionLink 006070 - Disclosure - Inventories link:presentationLink link:calculationLink link:definitionLink 006080 - Disclosure - Property, plant and equipment link:presentationLink link:calculationLink link:definitionLink 006090 - Disclosure - Long-term debt link:presentationLink link:calculationLink link:definitionLink 006100 - Disclosure - Line of credit link:presentationLink link:calculationLink link:definitionLink 006110 - Disclosure - Stockholders equity link:presentationLink link:calculationLink link:definitionLink 006130 - Disclosure - Income taxes link:presentationLink link:calculationLink link:definitionLink 006140 - Disclosure - Collaboration Agreements link:presentationLink link:calculationLink link:definitionLink 006150 - Disclosure - 401(k) savings plan link:presentationLink link:calculationLink link:definitionLink 006160 - Disclosure - Leases link:presentationLink link:calculationLink link:definitionLink 006170 - Disclosure - Litigation link:presentationLink link:calculationLink link:definitionLink 006180 - Disclosure - Variable interest entities link:presentationLink link:calculationLink link:definitionLink 006190 - Disclosure - Assets held for sale link:presentationLink link:calculationLink link:definitionLink 006200 - Disclosure - Related party transactions link:presentationLink link:calculationLink link:definitionLink 006210 - Disclosure - Restructuring link:presentationLink link:calculationLink link:definitionLink 006220 - Disclosure - Segment information link:presentationLink link:calculationLink link:definitionLink 006230 - Disclosure - Quarterly financial data (unaudited) link:presentationLink link:calculationLink link:definitionLink 000990 - Document - Document And Entity Information link:presentationLink link:calculationLink link:definitionLink 006120 - Disclosure - Earnings per share link:presentationLink link:calculationLink link:definitionLink 006240 - Disclosure - Intangible Assets and Goodwill link:presentationLink link:calculationLink link:definitionLink link:labelLink link:referenceLink 006250 - Disclosure - Notes Recievable link:presentationLink link:calculationLink link:definitionLink